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- Title
ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study.
- Authors
Girelli, Domenico; Martinelli, Nicola; Trabetti, Elisabetta; Olivieri, Oliviero; Cavallari, Ugo; Malerba, Giovanni; Busti, Fabiana; Friso, Simonetta; Pizzolo, Francesca; Pignatti, Pier Franco; Corrocher, Roberto
- Abstract
The aim of this study was to explore the role of variants of the gene encoding arachidonate 5-lipoxygenase-activating protein (ALOX5AP) as possible susceptibility factors for coronary artery disease (CAD) and myocardial infarction (MI) in patients with or without angiographically proven CAD. A total of 1431 patients with or without angiographically documented CAD were examined simultaneously for seven ALOX5AP single-nucleotide polymorphisms, allowing reconstruction of the at-risk haplotypes (HapA and HapB) previously identified in the Icelandic and British populations. Using a haplotype-based approach, HapA was not associated with either CAD or MI. On the other hand, HapB and another haplotype within the same region (that we named HapC) were significantly more represented in CAD versus CAD-free patients, and these associations remained significant after adjustment for traditional cardiovascular risk factors by logistic regression (HapB: odds ratio (OR) 1.67, 95% confidence interval (CI) 1.04–2.67; P=0.032; HapC: OR 2.41, 95% CI 1.09–5.32; P=0.030). No difference in haplotype distributions was observed between CAD subjects with or without a previously documented MI. Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI.European Journal of Human Genetics (2007) 15, 959–966; doi:10.1038/sj.ejhg.5201854; published online 16 May 2007
- Subjects
CORONARY disease; ANGIOGRAPHY; MYOCARDIAL infarction; HEART disease risk factors; GENETIC polymorphisms; LOGISTIC regression analysis
- Publication
European Journal of Human Genetics, 2007, Vol 15, Issue 9, p959
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201854