We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Subchronic Effects of Perfluorooctane Sulphonate on the Testicular Morphology and Spermatogenesis in Mice.
- Authors
De-Yong Zhang; Xiao-Lu Xu; Qin Ruan; Xiu-Ying Shen; Yin Lu
- Abstract
To determine the subchronic male reproductive toxicity of PFOS, male mice were administrated with a serial dosage of PFOS for 90 days for testicular observation and spermatogenesis evaluation. PFOS = 11 mg/kg (accumulative dosage) resulted in visible histopathological changing in testis, including disorder and vacuolization of spermatogenic cells. Changed testicular organ coefficient (for dosage = 55 mg/kg), decreased sperm concentration (for 110 mg/kg dosage), decreased motility (for 110 mg/kg dosage) and increased sperm malformation (for all of the treated groups) were also confirmed (p<0.05). Sperm malformation showed high sensitivity to PFOS exposure. A sperm malformation percentage, varying from 11.00% to 51.20%, was confirmed for the treated groups. As to various sperm malformation types, curved body type constituted the most proportion. The treated groups showed a curved body malformation percentage varied from 8.00% to 43.5%, due to different PFOS dosage. The observations indicate that subchronic exposure of PFOS can interfere with spermatogenesis process and affect sperm quality in mammals.
- Subjects
SPERMATOGENESIS; MORPHOLOGY; SPERMATOZOA; MICE; TESTIS; HUMAN abnormalities
- Publication
Pakistan Journal of Zoology, 2019, Vol 51, Issue 6, p2217
- ISSN
0030-9923
- Publication type
Article
- DOI
10.17582/journal.pjz/2019.51.6.2217.2223