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- Title
Effect of COVID-19 Pandemic on Neonatal Sepsis.
- Authors
Mahmoud, Ahmed M.; Alpakistany, Tariq A.; Ismail, Khadiga A.; Hawash, Yousry A.; Jaafar, Najwa; Mohamed, Medhat M.; Sami, Rokayya; Khalifa, Osama M.
- Abstract
Background: There is a sudden rise in infectious diseases, with special concern to the most recent SARS-CoV-2 outbreak. A retrospective study was conducted to study the effect of this outbreak on neonatal sepsis as a global issue that poses a challenge for pediatric management and to identify its risk factors, microbial profile, and mortality rate at King Faisal Medical Complex, Taif, KSA, a COVID-19-tertiary care segregation hospital. Methods: This research included 111 neonates with a culture-proven diagnosis of neonatal sepsis (4 and 62 cases during 2019 and 2020, respectively). Results: During 2019 early onset sepsis (EOS) occurred in 6/49 (12.2%) while in 2020 22/62 (35.5%), and during 2019 late onset sepsis (LOS) occurred in 43/49 (87.7%) while in 2020 40/62 (64.5%). Premature rupture of membrane was the major neonatal risk factor for EOS during 2019 and 2020 with proportions of 4 (66.7%), 20 (90.9%); respectively. As regards LOS, the peripherally inserted central catheters and peripheral lines were the top neonatal risk factors. In the two-year outbreak, the most prevalent causative organism for EOS neonates was Escherichia coli and for LOS neonates it was Klebsiella. There was non-significant change in the mortality rate of neonatal sepsis between 2019 and 2020. However, the mortality rate was higher in EOS 9/22 (40.9%) in 2020 in comparison to 2/6 (33.3%) in 2019. Conclusions: Neonatal sepsis remains a major health problem causing serious morbidity and mortality, and health care policy makers have to implement EOS preventive measures.
- Subjects
NEONATAL sepsis; PERIPHERALLY inserted central catheters; COVID-19 pandemic; CENTRAL venous catheters; COMMUNICABLE diseases; HEALTH policy
- Publication
Clinical Laboratory, 2022, Vol 68, Issue 5, p2251
- ISSN
1433-6510
- Publication type
Article
- DOI
10.7754/Clin.Lab.2021.210711