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- Title
Total Synthesis of Nosiheptide.
- Authors
Wojtas, K. Philip; Riedrich, Matthias; Lu, Jin‐Yong; Winter, Philipp; Winkler, Thomas; Walter, Sophia; Arndt, Hans‐Dieter
- Abstract
Total synthesis of the bismacrocyclic thiopeptide antibiotic nosiheptide was achieved through the assembly of a fully functionalized linear precursor followed by consecutive macrocyclizations. Key features are a critical macrothiolactonization and a mild deprotection strategy for the 3-hydroxypyridine core. The natural product was identical to isolated authentic material in terms of spectral data and antibiotic activity.
- Subjects
THIOPEPTIDES; ANTIBIOTICS; PEPTIDES; MACROCYCLIC compounds; SUSTAINABLE chemistry
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 33, p9772
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201603140