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- Title
The Intrinsic Fragility of DNA (Nobel Lecture).
- Authors
Lindahl, Tomas
- Abstract
The article discusses a laboratory experiment which examined the effects of increased temperatures and ions on the stability of DNA at different acidity (pH) levels, based on either Bacillus subtilis and Escherichia coli. Several changes were detected under these conditions including susceptibility to hydrolytic attack, oxidative damage and alkylation at guanine, cytosine, thymine and adenine sites. The role of antibody-producing cells in changing the DNA structure is mentioned.
- Subjects
DNA structure; BACILLUS subtilis; ESCHERICHIA coli; GUANINE; CYTOSINE
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 30, p8528
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201602159