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- Title
An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles.
- Authors
Bhonde, Vasudev R.; O'Neill, Brian T.; Buchwald, Stephen L.
- Abstract
The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ.
- Subjects
HALOALKANES; COUPLING reactions (Chemistry); AQUEOUS solutions; PHOSPHINE; OCTANOIC acid; CATALYTIC activity; ELECTROPHILES; ARYLATION
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 5, p1849
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201509341