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- Title
Phenylethynylcobalamin: A Light-Stable and Thermolysis-Resistant Organometallic Vitamin B<sub>12</sub> Derivative Prepared by Radical Synthesis.
- Authors
Ruetz, Markus; Salchner, Robert; Wurst, Klaus; Fedosov, Sergey; Kräutler, Bernhard
- Abstract
Don't take this antivitamin! 2‐Phenylethynylcobalamin (see picture) was prepared in a newly developed radical reaction using cob(II)alamin and 1‐iodo‐2‐phenylethyne. It has an exceptionally short organometallic bond and is a remarkably light‐stable and heat‐resistant organometallic cobalamin. It is bound well by two important proteins of the human B12 transport system and has properties that are as expected for a new type of an “antivitamin B12”.
- Subjects
VITAMIN B12 deficiency; ETHYNYL benzene; INTRINSIC factor (Physiology); MAMMALS; MUCOPROTEINS; CHEMICAL decomposition
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 43, p11406
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201305206