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- Title
Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes.
- Authors
Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
- Abstract
The article discusses research on malate dehydrogenase 2 as a target protein of the hypoxia-inducible factor (HIF)-1 inhibitor LW6 through chemical probes. It talks about the regulation by HIF of tumor angiogenesis and metastasis in relation to oxygen tension. It also offers information on the assessment of aryloxyacetul-amino benzoic acid analogues.
- Subjects
CLICK chemistry; FLUORESCENT probes; HYPOXIA-inducible factor 1; PHOTOAFFINITY labeling; AFFINITY labeling
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 39, p10286
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201304987