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- Title
Ectopic production of 1,25-dihydroxyvitamin D by B-cell lymphoma as a cause of hypercalcemia.
- Authors
Mudde, Aart H.; Berg, Henk Van Den; Boshuis, Peter G.; Breedveld, Ferdinand C.; Markusse, Harry M.; Kluin, Phillip M.; Bijvoet, Olav L. M.; Papapoulos, Socrates E.; Mudde, A H; van den Berg, H; Boshuis, P G; Breedveld, F C; Markusse, H M; Kluin, P M; Bijvoet, O L; Papapoulos, S E
- Abstract
A patient with long-standing rheumatoid arthritis developed hypercalcemia (3.13 mmol/l) and was subsequently found to have a B-cell lymphoma (centroblastic type). The hypercalcemia was associated with high circulating concentrations of 1,25-dihydroxyvitamin D (235 pmol/l) and both abnormalities were corrected with treatment. A lymph node was excised before treatment and was incubated in vitro with either labeled or unlabeled 25-hydroxyvitamin D3. After purification of the extract and chromatography on three different HPLC systems, material comigrating with authentic 1,25-dihydroxyvitamin D3 was identified. This was shown to bind to a specific chick intestinal cytosol receptor and to dilute in parallel with synthetic 1,25-dihydroxyvitamin D3 in the receptor binding assay. In conclusion, hypercalcemia in malignant B-cell lymphoma can be due to extrarenal production of 1,25-dihydroxyvitamin D by lymphomatous tissue.
- Publication
Cancer (0008543X), 1987, Vol 59, Issue 9, p1543
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19870501)59:9<1543::AID-CNCR2820590902>3.0.CO;2-L