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- Title
Novel RHD allele with c.333C>G change predicted to encode p.Phe111Leu.
- Authors
Alluin, Gauthier; Durieux‐Roussel, Elisabeth; Fayoux, Pierre; Pirenne, France; Tournamille, Christophe; Floch, Aline; Durieux-Roussel, Elisabeth
- Abstract
Intraprotein interaction analysis predicted a single hydrophobic interaction for the consensus p.Phe111 residue, while the change to p.Leu111 was predicted to form one hydrophobic interaction with p.Leu115 and hydrogen bonds between main chains and p.Thr109, p.Ile113, p.Arg114, and p.Leu115. Abbreviation RBC red blood cells INTRODUCTION The D (RH1) antigen is a major antigen in immunohematology, both from a transfusion point of view due to its immunogenicity and polymorphism, but also from an obstetrical point of view. By the Biorad ID partial RhD typing set, the RBCs were non-reactive with LHM70/45, weakly reactive (1+ SP w sp ) with LHM59/19, and positive with all other clones (3+).
- Subjects
ALLELES; RH factor; GENES; GENOTYPES; PHENOTYPES
- Publication
Transfusion, 2022, Vol 62, Issue 10, pE63
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.17072