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- Title
Integrative genomic and transcriptomic analysis reveals immune subtypes and prognostic markers in ovarian clear cell carcinoma.
- Authors
Ye, Shuang; Li, Qin; Wu, Yutuan; Jiang, Wei; Zhou, Shuling; Zhou, Xiaoyan; Yang, Wentao; Tu, Xiaoyu; Shan, Boer; Huang, Shenglin; Yang, Huijuan
- Abstract
<bold>Background: </bold>We performed an integrative genomic and transcriptomic profiling to identify molecular subtypes and prognostic markers with special focus on immune-related pathways.<bold>Methods: </bold>Totally, 50 Chinese patients were subjected to targeted next-generation sequencing and transcriptomic sequencing.<bold>Results: </bold>Two distinct subgroups were identified as immune (22.0%) and non-immune (78.0%) based on the immune-pathway related hierarchical clustering. Surprisingly, patients with immune subtype had a significantly worse survival. The prognostic capacity was validated in external cohorts. The immune group had higher expression of genes involved in pro-inflammation and checkpoints. PD-1 signalling pathway was enriched in the immune subtype. Besides, the immune cluster presented enriched expression of genes involved in epithelial-mesenchymal transition, angiogenesis and PI3K-AKT-mTOR signalling, while the non-immune subtype had higher expression of metabolic pathways. The immune subtype had a higher mutation rate of PIK3CA though significance was not achieved. Lastly, we established a prognostic immune signature for overall survival. Interestingly, the immune signature could also be applied to renal clear cell carcinoma, but not to other histologic subtype of ovarian cancer.<bold>Conclusions: </bold>An immune subtype of OCCC was identified with poor survival and enrichment of PD-1 and PI3K-AKT-mTOR signalling. We constructed and validated a robust prognostic immune signature of OCCC patients.
- Publication
British Journal of Cancer, 2022, Vol 126, Issue 8, p1215
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-022-01705-w