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- Title
Durability of antiviral response in HBeAg-positive chronic hepatitis B patients who maintained virologic response for one year after lamivudine discontinuation.
- Authors
Kim, Ji; Lee, Sun Jae; Joo, Moon Kyung; Kim, Chung Ho; Choi, Jong Hwan; Jung, Young Kul; Yim, Hyung Joon; Yeon, Jong Eun; Park, Jong-Jae; Kim, Jae Seon; Bak, Young Tae; Byun, Kwan Soo; Kim, Ji Hoon
- Abstract
The purpose of this study is to determine the long-term relapse rate and associated risk factors in HBeAg-positive chronic hepatitis B (CHB) patients who had maintained virologic response (VR) for 1 year after lamivudine (LMV) discontinuation. We enrolled 55 treatment-naive HBeAg-positive CHB patients who achieved and maintained VR until 1 year after LMV discontinuation. Delayed relapse was defined as an elevation of HBV DNA after sustained VR for 1 year. During follow-up, 16 of 55 patients (29%) showed delayed relapse. Beginning 1 year after LMV discontinuation, the cumulative rates of relapse after 2 and 4 years were 29 and 44%, respectively. In multivariate analysis, age (P = 0.029) and >2,000 copies/ml HBV DNA 3 months after LMV discontinuation (P = 0.047) were significant predictors of delayed relapse. Delayed relapse is not infrequent, even in patients who maintain VR for 1 year after LMV discontinuation. Therefore, LMV maintenance therapy might be considered in HBeAg-positive CHB patients who achieve VR.
- Subjects
ANTIVIRAL agents; HEPATITIS B; MEDICAL virology; DISEASE relapse; TERMINATION of treatment; MULTIVARIATE analysis; PATIENTS; COMPARATIVE studies; DNA; HEPATITIS viruses; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RADIOIMMUNOASSAY; RESEARCH; VIRAL antigens; VIRAL load; EVALUATION research; DISEASE remission; RETROSPECTIVE studies; LAMIVUDINE; REVERSE transcriptase inhibitors; CHRONIC hepatitis B
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 7, p1572
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0508-3