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- Title
A natural allele of Nxf1 suppresses retrovirus insertional mutations.
- Authors
Floyd, Jennifer A.; Gold, David A.; Concepcion, Dorothy; Poon, Tiffany H.; Xiaobo Wang, Tiffany H.; Keithley, Elizabeth; Chen, Dan; Ward, Erica J.; Chinn, Steven B.; Friedman, Rick A.; Hon-Tsen Yu; Moriwaki, Kazuo; Shiroishi, Toshihiko; Hamilton, Bruce A.
- Abstract
Endogenous retroviruses have shaped the evolution of mammalian genomes. Host genes that control the effects of retrovirus insertions are therefore of great interest. The modifier-of-vibrator-1 locus (Mvb1) controls levels of correctly processed mRNA from genes mutated by endogenous retrovirus insertions into introns, including the Pitpnvb tremor mutation and the Eya1BOR model of human branchiootorenal syndrome. Positional complementation cloning identifies Mvb1 as the nuclear export factor Nxf1, providing an unexpected link between the mRNA export receptor and pre-mRNA processing. Population structure of the suppressive allele in wild Mus musculus castaneus suggests selective advantage. A congenic Mvb1CAST allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements.
- Subjects
RETROVIRUS genetics; RETROVIRUSES; GENETIC mutation; GENOMES; MESSENGER RNA; CLONING; GENETICS; BIOLOGICAL evolution
- Publication
Nature Genetics, 2003, Vol 35, Issue 3, p221
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1247