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- Title
The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men.
- Authors
Eendebak, Robert J. A. H.; Huhtaniemi, Ilpo T.; Pye, Stephen R.; Ahern, Tomas; O'Neill, Terence W.; Bartfai, György; Casanueva, Felipe F.; Maggi, Mario; Forti, Gianni; Alston, Robert D.; Giwercman, Aleksander; Han, Thang S.; Kula, Krzysztof; Lean, Michael E. J.; Punab, Margus; Pendleton, Neil; Keevil, Brian G.; Vanderschueren, Dirk; Rutter, Martin K.; Tampubolon, Gindo
- Abstract
Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.Conclusion: Within a 4-year time frame, variations in the AR CAG repeat do not contribute to the rate of phenotypic ageing, over and above, which might be associated with the age-related decline in T levels.
- Subjects
ANDROGEN receptors; GENETICS of aging; HEALTH of older men; ANDROGENS; ESTRADIOL
- Publication
European Journal of Endocrinology, 2016, Vol 175, Issue 6, p583
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-16-0447