We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Multiple aberrant hormone receptors in Cushing's syndrome.
- Authors
El Ghorayeb, Nada; Bourdeau, Isabelle; Lacroix, André
- Abstract
The mechanisms regulating cortisol production when ACTH of pituitary origin is suppressed in primary adrenal causes of Cushing's syndrome (CS) include diverse genetic and molecular mechanisms. These can lead either to constitutive activation of the cAMP system and steroidogenesis or to its regulation exerted by the aberrant adrenal expression of several hormone receptors, particularly G-protein coupled hormone receptors (GPCR) and their ligands. Screening for aberrant expression of GPCR in bilateral macronodular adrenal hyperplasia (BMAH) and unilateral adrenal tumors of patients with overt or subclinical CS demonstrates the frequent co-expression of several receptors. Aberrant hormone receptors can also exert their activity by regulating the paracrine secretion of ACTH or other ligands for those receptors in BMAH or unilateral tumors. The aberrant expression of hormone receptors is not limited to adrenal CS but can be implicated in other endocrine tumors including primary aldosteronism and Cushing's disease. Targeted therapies to block the aberrant receptors or their ligands could become useful in the future.
- Subjects
HORMONE receptors; CUSHING'S syndrome; G protein coupled receptors; CARNEY complex; ADENYLATE cyclase
- Publication
European Journal of Endocrinology, 2015, Vol 173, Issue 4, pM45
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-15-0200