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- Title
Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium.
- Authors
Machens, Andreas; Lorenz, Kerstin; Sekulla, Carsten; Höppner, Wolfgang; Frank-Raue, Karin; Raue, Friedhelm; Dralle, Henning
- Abstract
Objective: Twenty years ago, the groundbreaking discovery that rearranged during transfection (RET) mutations underlie multiple endocrine neoplasia 2 (MEN2) and familial medullary thyroid eancer (EMTC) ushered in the era of personalized medicine, MEN2-associated signs, taking time to manifest, can be subtle, This study sought to clarify to what extent conventional estimates of 1 :200 000-500 000 underestimate the incidence of RET mutations in the population. Design: Included in this retrospective investigation were 333 RET carriers born between 1951 and 2000 and operated on at the largest German surgical referral center (286 carriers) or elsewhere (47 carriers). Methods: To estimate the incidence of RET mutations, the number of RET carriers born in Germany in five decades (1951-1960, 1961-1970, 1971-1980, 1981-1990, and 1991-2000) was divided by the corresponding number of German live births. Results: Owing to improved diagnosis and capture of FMTC and MEN2 patients, minimum incidence estimates increased over time: overall from 5.0 (1951-1960) to 9.9 (1991-2000) per million live births and year (P: 0.008), and by American Thyroid Association/ATA class lrom 1.7 to 3.7 for ATA class C (P=0.008); from 1,8 to 2.7 for ATA class A (P=0.017): from 1.5 to 2.2 for ATA class B (P=0.20): and from 0 to 1.4 for ATA class D mutations per million live births and year (P=0.008). Based on 1991-2000 incidence estimates the prevalence in Germany is ∼ 1:80 0()0 inhabitants. Conclusions: The molecular minimum incidence estimate of ≈ 1:100 000 was two- to iivefold greater than conventional estimates of 1:200 000-500 000.
- Subjects
ENDOCRINE gland cancer; MOLECULAR epidemiology; GENE transfection; GENETIC mutation; ENDOCRINOLOGY
- Publication
European Journal of Endocrinology, 2013, Vol 168, Issue 3, p307
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-12-0919