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- Title
Cerebrospinal fluid nitrite/nitrate predicts poor outcome in patients with subarachnoid hemorrhage (SAH).
- Authors
Rejdak, K.; Petzold, A.; Sharpe, M. A.; Kay, A. D.; Kerr, M.; Stelmasiak, Z.; Thompson, E. J.; Giovannoni, G.
- Abstract
The study aimed to relate CSF levels of nitric oxide metabolites and oxyhemoglobin (OxyHb) to the clinical outcome measures in patients after SAH. The study group comprised 10 SAH patients and 10 controls. CSF total nitrite/nitrate (NOx) concentration was measured by a vanadium-based assay while OxyHb level by spectrophotometry. There was a significant correlation between CSF concentrations of NOx and OxyHb (P = 0.001, r = 0.87). When the impact of bleeding into CSF was considered, patients with good outcome had significantly lower CSF NOx than those with bad outcome (P = 0.007). This study demonstrates that after SAH, CSF NOx levels correlate with OxHb and high CSF NOx predicted poor outcome.
- Subjects
NITRIC oxide; METABOLITES; OXYHEMOGLOBIN
- Publication
Journal of Neurochemistry, 2003, Vol 85, p25
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.85.s2.18_8.x