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- Title
Comprehensive proteomic profiling of serum extracellular vesicles in patients with colorectal liver metastases identifies a signature for non-invasive risk stratification and early-response evaluation.
- Authors
Lin, Kuailu; Baenke, Franziska; Lai, Xixi; Schneider, Martin; Helm, Dominic; Polster, Heike; Rao, Venkatesh S.; Ganig, Nicole; Wong, Fang Cheng; Seifert, Lena; Seifert, Adrian M.; Jahnke, Beatrix; Kretschmann, Nicole; Ziemssen, Tjalf; Klupp, Fee; Schmidt, Thomas; Han, Yi; Weber, Tim F.; Plodeck, Verena; Nebelung, Heiner
- Abstract
In independent validation cohorts, the level of EVP concentration was higher in CRLM patients compared to BD patients ( I p i = 0.04; Fig. Quantification of EVPs from human serum samples A Boxplot analysis of EVP concentration in the discovery cohort. Kaplan-Meier curves of the validation cohorts indicated that the EVP signature could distinguish between the risk of recurrence and death of CRLM patients (internal: p < 0.0001 and external: I p i = 0.004 validation cohort; Fig.
- Subjects
COLORECTAL liver metastasis; EXTRACELLULAR vesicles; LIQUID chromatography-mass spectrometry; SHOTGUN sequencing; CLINICAL prediction rules; PROTEOMICS; DISEASE risk factors
- Publication
Molecular Cancer, 2022, Vol 21, Issue 1, p1
- ISSN
1476-4598
- Publication type
Letter
- DOI
10.1186/s12943-022-01562-4