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- Title
Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease.
- Authors
Rajasekaran, Santhanasabapathy; Witt, Stephan N.
- Abstract
In Parkinson disease (PD), Lewy bodies (LBs) form in the gut or nose and spread into the midbrain. A study in this issue indicates that the spread is due to lysosomes "infected" with prion-like alpha-synuclein (α-syn) transmitting from cell to cell via tunneling nanotubes (TNTs). In Parkinson's disease, Lewy bodies form in the gut or nose and spread into the midbrain. This Primer explores the implications of a study indicating that this spread is due to lysosomes "infected" with prion-like α-synuclein transmitting from cell-to-cell via tunneling nanotubes.
- Subjects
PARKINSON'S disease; INFECTIOUS disease transmission; NANOTUBES; TUNNEL design &; construction; TUNNELS; ELECTRONIC noses
- Publication
PLoS Biology, 2021, Vol 19, Issue 7, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.3001331