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- Title
Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
- Authors
Eryilmaz, Ozlem; Devran, Aysun; Sarikaya, Esma; Aksakal, Fatma; Mollamahmutoğlu, Leyla; Cicek, Nedim
- Abstract
Purpose: We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin. Methods: A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n = 30) had underwent the IVF-ET with melatonin administration and the control group (group B, n = 30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups. Results: Sleeping status change was not significant ( p > 0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p = 0.0001; p = 0.0001; p < 0.05 respectively. Conclusion: IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.
- Subjects
MELATONIN; OVUM; EMBRYOS; HUMAN in vitro fertilization; SLEEP disorders; CONTROL groups; GENETIC engineering
- Publication
Journal of Assisted Reproduction & Genetics, 2011, Vol 28, Issue 9, p815
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-011-9604-y