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- Title
TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes.
- Authors
Zhou, Xinyu; Li, Ang; Lin, Pei-hui; Zhou, Jingsong; Ma, Jianjie
- Abstract
Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B−/− mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A−/− mice survive normally but show abnormal SR Ca2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca2+ signaling of cardiomyocytes and discuss the current knowledge gaps.
- Publication
Pflügers Archiv: European Journal of Physiology, 2021, Vol 473, Issue 3, p547
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-021-02513-6