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- Title
Neolignans from the Fruits of Magnolia obovata Inhibit NO Production and Have Neuroprotective Effects.
- Authors
Seo, Kyeong‐Hwa; Lee, Dae‐Young; Jung, Jae‐Woo; Lee, Dong‐Sung; Kim, Youn‐Chul; Lee, Youn‐Hyung; Baek, Nam‐In
- Abstract
One new sesquineolignan, obovatalignan A ( 1), and one new neolignan, obovatalignan B ( 2), were isolated from the Magnolia obovata fruits. Their chemical structure, including absolute configuration, was determined based on various spectroscopic methods, such as HR- EI-MS, 1D- NMR (1H, 13C, DEPT), 2D- NMR ( gCOSY, gHSQC, gHMBC, NOESY), and CD spectroscopy. The compounds were evaluated for protective effects against glutamate-induced oxidative stress in HT22-immortalized hippocampal cells and inhibitory activity against NO production in LPS-induced RAW 264.7 cells. Compounds 1 and 2 exhibited protective effects against glutamate-induced oxidative stress with EC50 values of 18.1 ± 1.23 and 7.10 ± 0.78 μ m, respectively, as well as inhibitory effects on NO production with IC50 values of > 30.0 and 8.22 ± 2.01 μ m, respectively.
- Subjects
MAGNOLIAS; NEOLIGNANS; FRUIT composition; NITRIC oxide; NEUROPROTECTIVE agents; OXIDATIVE stress
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 6, p411
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500101