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- Title
Synthesis of Novel Pyrazino[2,1- a]isoindolediones via Intramolecular Hydroamination of 2,3-Dihydro-3-oxo-2-(prop-2-yn-1-yl)-1 H-isoindole-1-carboxamides.
- Authors
Esmaeili‐Marandi, Fatemeh; Yavari, Issa; Saeedi, Mina; Mahdavi, Mohammad; Shafiee, Abbas
- Abstract
Novel derivatives of pyrazino[2,1- a]isoindolediones were synthesized through 6- exo- dig intramolecular hydroamination of 2,3-dihydro-3-oxo-2-(prop-2-yn-1-yl)-1 H-isoindole-1-carboxamides followed by 1,3-H shift, in the presence of sodium hydride in DMF at 80°. All products were obtained in good yields (60 - 80%) within short reaction time (40 - 60 min).
- Subjects
PYRAZINONES; CHEMICAL synthesis; INTRAMOLECULAR catalysis; HYDROAMINATION; CARBOXAMIDES; SODIUM hydride
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 3, p187
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500168