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- Title
Cooperative effect of serum 25-hydroxyvitamin D concentration and a polymorphism of transforming growth factor-beta1 gene on the prevalence of vertebral fractures in postmenopausal osteoporosis.
- Authors
Mori, Seijiro; Fuku, Noriyuki; Chiba, Yuko; Tokimura, Fumiaki; Hosoi, Takayuki; Kimbara, Yoshiyuki; Tamura, Yoshiaki; Araki, Atsushi; Tanaka, Masashi; Ito, Hideki
- Abstract
A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to assess a possible cooperative effect of the gene polymorphism and vitamin D status on vertebral fracture risk. The prevalence of vertebral fracture in 168 postmenopausal female patients with osteoporosis was analyzed, and its association with the TGF-beta1 gene polymorphism and serum 25(OH)D concentration was assessed cross-sectionally. The fracture prevalence increased according to the rank order of the TGF-beta1 genotypes CC < CT < TT, as expected. A significant difference was found not only between the CC and TT genotypes (P = 0.005) but also between the CC and CT genotypes (P < 0.05) when the patients with serum 25(OH)D of more than the median value [22 ng/ml (55 nmol/l)] were analyzed. On the other hand, when those with serum 25(OH)D of less than the median value were analyzed, the protective effect of the C allele against the fracture was blunted; statistical significance in the difference of the fracture prevalence was lost between the CC genotype and the other genotypes. These data suggest that vitamin D fulfillment is prerequisite for the TGF-beta1 genotype in exerting its full effect on the fracture prevalence.
- Subjects
OSTEOPOROSIS; BONE diseases; GENETIC polymorphisms; TRANSFORMING growth factors; HIP joint injuries; BONE fractures; GROWTH factors; SPINAL injuries; VITAMIN D; PHOTON absorptiometry; GENOTYPES
- Publication
Journal of Bone & Mineral Metabolism, 2010, Vol 28, Issue 4, p446
- ISSN
0914-8779
- Publication type
journal article
- DOI
10.1007/s00774-009-0147-6