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- Title
History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience.
- Authors
Hedrick, Holly L; Flake, Alan W; Crombleholme, Timothy M; Howell, Lori J; Johnson, Mark P; Wilson, R Douglas; Adzick, N Scott
- Abstract
Since its inception in 1995, the mission of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia (CHOP) has been to provide comprehensive, multidisciplinary expertise in all facets of prenatal diagnosis, reproductive genetics, and prenatal, perinatal, and postnatal treatment for abnormal fetuses. Most of the authors were trained and/or served on faculty at centers in San Francisco (N.S.A., A.W.F., T.M.C., L.J.H.) or Detroit (A.W.F, M.P.J.). Accurate prenatal detection by serial sonographic study and the development of ultrafast magnetic resonance imaging (MRI) scanners has permitted delineation of the natural history of anatomic malformations. Definition of the pathophysiological features that affect clinical outcome and formulation of management based on prognosis has allowed families to make informed decisions. Outcomes have been improved through carefully planned and coordinated perinatal management. In some cases of life-threatening or severely debilitating defects, prenatal surgery has been offered.
- Subjects
PENNSYLVANIA; DIAGNOSIS of fetal diseases; ACADEMIC medical centers; FETAL diseases; FETAL ultrasonic imaging; PRENATAL diagnosis; THERAPEUTICS
- Publication
Fetal Diagnosis & Therapy, 2003, Vol 18, Issue 2, p65
- ISSN
1015-3837
- Publication type
journal article
- DOI
10.1159/000068075