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- Title
Endothelial Function, Oxidative Stress and Inflammatory Studies in Chronic Coronary Slow Flow Phenomenon Patients.
- Authors
Kopetz, Victoria; Kennedy, Jennifer; Heresztyn, Tamila; Stafford, Irene; Willoughby, Scott R.; Beltrame, John F.
- Abstract
The coronary slow flow phenomenon (CSFP) is associated with coronary microvascular dysfunction although the responsible mechanisms are unknown. This study compared endothelial function assessed by changes in augmentation index (AIx) following endothelium-independent (glyceryl trinitrate, GTN) and endothelium-dependent vasodilators (salbutamol), in 40 stable CSFP patients and 23 age-matched healthy controls. Plasma concentrations of inflammatory proteins (myeloperoxidase and high-sensitivity C-reactive protein), oxidative stress biomarkers (malondialdehyde and homocysteine), and asymmetric dimethylarginine levels were also determined. There were no differences between CSFP and controls in response to salbutamol (AIx: -2.28 ± 0.88% vs. -3.22 ± 0.70%, p = 0.4) or GTN (AIx: -11.30 ± 0.75% vs. -13.30 ± 1.00%, p = 0.12). Similarly, there were no differences in the measured biomarkers. Thus, alternate mechanisms to the assessed endothelial function, inflammatory and oxidative stress processes should be explored to explain the microvascular dysfunction in CSFP patients. Copyright © 2012 S. Karger AG, Basel
- Subjects
OXIDATIVE stress; MICROCIRCULATION disorders; PULMONARY endothelium; CORONARY disease; VASODILATORS; BIOMARKERS; PATIENTS
- Publication
Cardiology, 2012, Vol 121, Issue 3, p197
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000336948