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- Title
Identification of Risk Loci for Necrotizing Meningoencephalitis in Pug Dogs.
- Authors
Barber, Renee M.; Schatzberg, Scott J.; Corneveaux, Jason J.; Allen, April N.; Porter, Brian F.; Pruzin, Jeremy J.; Platt, Simon R.; Kent, Marc; Huentelman, Matthew J.
- Abstract
Due to their unique population structure, purebred dogs have emerged as a key model for the study of complex genetic disorders. To evaluate the utility of a newly available high-density canine whole-genome array with >170 000 single nucleotide polymorphisms (SNPs), genome-wide association was performed on a small number of case and control dogs to determine disease susceptibility loci in canine necrotizing meningoencephalitis (NME), a disorder with known non-Mendelian inheritance that shares clinical similarities with atypical variants of multiple sclerosis in humans. Genotyping of 30 NME-affected Pug dogs and 68 healthy control Pugs identified 2 loci associated with NME, including a region within dog leukocyte antigen class II on chromosome 12 that remained significant after Bonferroni correction. Our results support the utility of this high-density SNP array, confirm that dogs are a powerful model for mapping complex genetic disorders and provide important preliminary data to support in depth genetic analysis of NME in numerous affected breeds.
- Subjects
GENETIC disorders in animals; DOG genetics; SINGLE nucleotide polymorphisms; MENINGOENCEPHALITIS; GENE mapping; MAMMALS
- Publication
Journal of Heredity, 2011, Vol 102, pS40
- ISSN
0022-1503
- Publication type
Article
- DOI
10.1093/jhered/esr048