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- Title
Serum separation abnormality in a multiple myeloma patient.
- Authors
ZAHARUDIN, Mohd Radzli; THAMBIAH, Subashini C.; SAMSUDIN, Intan Nureslyna; HAMID, Hanisah A.
- Abstract
Introduction: M-protein secreted by myeloma cells do not only contribute to myeloma-related complications but is also a well-recognised source of interference in laboratory assays. We describe a case of a 62-year-old woman whose blood sample showed improper serum separation even after resampling. Case report: Centrifugation of a biochemistry specimen in a serum-separator tube received by the laboratory failed to separate any serum, nor did repeating the process at a longer duration. Repeat sampling only yielded a small volume of serum from which highly elevated total protein was noted upon analysis. Additional history from the treating clinician unveiled a diagnosis of multiple myeloma in this patient. Discussion: This case represents one of the rare, but significant pre-analytical interferences caused by M-proteins.
- Subjects
MULTIPLE myeloma; HUMAN abnormalities; BLOOD sampling; CENTRIFUGATION
- Publication
Malaysian Journal of Pathology, 2023, Vol 45, Issue 1, p123
- ISSN
0126-8635
- Publication type
Case Study