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- Title
Intraperitoneal Fat Is Associated With Thickening of the Thoracic Aorta in Individuals at High Risk for Cardiovascular Events.
- Authors
Chughtai, Haroon L.; Morgan, Timothy M.; Hamilton, Craig A.; Charoenpanichkit, Charaslak; Ding, Jingzhong; Brinkley, Tina E.; Hundley, W. Gregory
- Abstract
Increased intraperitoneal (IP) fat is associated with increased cardiovascular (CV) risk, but mechanisms for this increase in risk are not completely established. We performed this study to assess whether IP fat is associated with ascending aortic wall thickness (AOWT), a risk factor for CV events. Four hundred and forty-one consecutive participants, aged 55-85 years, with risk factors for CV events underwent magnetic resonance measures of AOWT and abdominal fat (subcutaneous (SC) fat + IP fat). For the ascending aorta, mean wall thickness of the 4th quartile of the IP fat was higher relative to the 1st quartile (P ≤ 0.001). This difference persisted after accounting for SC fat (P ≤ 0.001), as well as age, gender, height, weight, smoking, diabetes, hypertension, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and C-reactive protein (CRP) (P < 0.03). Elevated IP fat volume is associated with an increase in ascending AOWT, a condition that promotes CV events in middle aged and elderly adults.
- Subjects
ADIPOSE tissues; THORACIC aneurysms; CARDIOVASCULAR diseases; PERITONEUM diseases; HIGH density lipoproteins
- Publication
Obesity (19307381), 2011, Vol 19, Issue 9, p1784
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2011.188