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Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions.
Published in:
Journal of Neuroscience, 2004, v. 24, n. 31, p. 7024, doi. 10.1523/JNEUROSCI.1863-04.2004
By:
- Bjerggaard, Christian;
- Fog, Jacob U.;
- Hastrup, Hanne;
- Madsen, Kenneth;
- Loland, Claus J.;
- Javitch, Jonathan A.;
- Gether, Ulrik
Publication type:
Article
Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.
Published in:
eLife, 2017, p. 1, doi. 10.7554/eLife.19314
By:
- Erlendsson, Simon;
- Gotfryd, Kamil;
- Larsen, Flemming Hofmann;
- Mortensen, Jonas Sigurd;
- Geiger, Michel-Andreas;
- van Rossum, Barth-Jan;
- Oschkinat, Hartmut;
- Gether, Ulrik;
- Teilum, Kaare;
- Loland, Claus J.
Publication type:
Article
The dopamine transporter antiports potassium to increase the uptake of dopamine.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30154-5
By:
- Schmidt, Solveig G.;
- Malle, Mette Galsgaard;
- Nielsen, Anne Kathrine;
- Bohr, Søren S.-R.;
- Pugh, Ciara F.;
- Nielsen, Jeppe C.;
- Poulsen, Ida H.;
- Rand, Kasper D.;
- Hatzakis, Nikos S.;
- Loland, Claus J.
Publication type:
Article
The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25363-3
By:
- Plenge, Per;
- Yang, Dongxue;
- Salomon, Kristine;
- Laursen, Louise;
- Kalenderoglou, Iris E.;
- Newman, Amy H.;
- Gouaux, Eric;
- Coleman, Jonathan A.;
- Loland, Claus J.
Publication type:
Article
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.
Published in:
Nature Methods, 2010, v. 7, n. 12, p. 1003, doi. 10.1038/nmeth.1526
By:
- Pil Seok Chae;
- Rasmussen, Søren G F;
- Rana, Rohini R.;
- Gotfryd, Kamil;
- Chandra, Richa;
- Goren, Michael A.;
- Kruse, Andrew C.;
- Nurva, Shailika;
- Loland, Claus J.;
- Pierre, Yves;
- Drew, David;
- Popot, Jean-Luc;
- Picot, Daniel;
- Fox, Brian G.;
- Lan Guan;
- Gether, Ulrik;
- Byrne, Bernadette;
- Kobilka, Brian;
- Gellman, Samuel H.
Publication type:
Article
Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas.
Published in:
Plant Journal, 2022, v. 111, n. 4, p. 936, doi. 10.1111/tpj.15866
By:
- Semple, Susan J.;
- Staerk, Dan;
- Buirchell, Bevan J.;
- Fowler, Rachael M.;
- Gericke, Oliver;
- Kjaerulff, Louise;
- Zhao, Yong;
- Pedersen, Hans Albert;
- Petersen, Malene J.;
- Rasmussen, Line Fentz;
- Bredahl, Emilie Kold;
- Pedersen, Gustav Blichfeldt;
- McNair, Laura Mikél;
- Ndi, Chi P.;
- Hansen, Nikolaj Lervad;
- Heskes, Allison M.;
- Bayly, Michael J.;
- Loland, Claus J.;
- Heinz, Nanna;
- Møller, Birger Lindberg
Publication type:
Article
Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila.
Published in:
Plant Journal, 2021, v. 108, n. 2, p. 555, doi. 10.1111/tpj.15448
By:
- Gericke, Oliver;
- Fowler, Rachael M.;
- Heskes, Allison M.;
- Bayly, Michael J.;
- Semple, Susan J.;
- Ndi, Chi P.;
- Stærk, Dan;
- Løland, Claus J.;
- Murphy, Daniel J.;
- Buirchell, Bevan J.;
- Møller, Birger Lindberg
Publication type:
Article
Substrate-induced conformational dynamics of the dopamine transporter.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10449-w
By:
- Nielsen, Anne Kathrine;
- Möller, Ingvar R.;
- Wang, Yong;
- Rasmussen, Søren G. F.;
- Lindorff-Larsen, Kresten;
- Rand, Kasper D.;
- Loland, Claus J.
Publication type:
Article
Conformational dynamics of the human serotonin transporter during substrate and drug binding.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09675-z
By:
- Möller, Ingvar R.;
- Slivacka, Marika;
- Nielsen, Anne Kathrine;
- Rasmussen, Søren G. F.;
- Gether, Ulrik;
- Loland, Claus J.;
- Rand, Kasper D.
Publication type:
Article
Glyco‐Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study.
Published in:
ChemBioChem, 2022, v. 23, n. 7, p. 1, doi. 10.1002/cbic.202200027
By:
- Ehsan, Muhammad;
- Wang, Haoqing;
- Katsube, Satoshi;
- Munk, Chastine F.;
- Du, Yang;
- Youn, Taeyeol;
- Yoon, Soyoung;
- Byrne, Bernadette;
- Loland, Claus J.;
- Guan, Lan;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy.
Published in:
ChemBioChem, 2018, v. 19, n. 20, p. 2225, doi. 10.1002/cbic.201800388
By:
- Das, Manabendra;
- Du, Yang;
- Mortensen, Jonas S.;
- Hariharan, Parameswaran;
- Lee, Hyun Sung;
- Byrne, Bernadette;
- Loland, Claus J.;
- Guan, Lan;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability.
Published in:
ChemBioChem, 2018, v. 19, n. 13, p. 1433, doi. 10.1002/cbic.201800106
By:
- Ehsan, Muhammad;
- Das, Manabendra;
- Stern, Valerie;
- Du, Yang;
- Mortensen, Jonas S.;
- Hariharan, Parameswaran;
- Byrne, Bernadette;
- Loland, Claus J.;
- Kobilka, Brian K.;
- Guan, Lan;
- Chae, Pil Seok
Publication type:
Article
Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.
Published in:
ChemBioChem, 2016, v. 17, n. 24, p. 2334, doi. 10.1002/cbic.201600429
By:
- Cho, Kyung Ho;
- Hariharan, Parameswaran;
- Mortensen, Jonas S.;
- Du, Yang;
- Nielsen, Anne K.;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Loland, Claus J.;
- Guan, Lan;
- Chae, Pil Seok
Publication type:
Article
Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation.
Published in:
ChemBioChem, 2015, v. 16, n. 10, p. 1454, doi. 10.1002/cbic.201500151
By:
- Bae, Hyoung Eun;
- Gotfryd, Kamil;
- Thomas, Jennifer;
- Hussain, Hazrat;
- Ehsan, Muhammad;
- Go, Juyeon;
- Loland, Claus J.;
- Byrne, Bernadette;
- Chae, Pil Seok
Publication type:
Article
Exploring the K<sup>+</sup> binding site and its coupling to transport in the neurotransmitter: sodium symporter LeuT.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.87985
By:
- Schmidt, Solveig G.;
- Nygaard, Andreas;
- Mindell, Joseph A.;
- Loland, Claus J.
Publication type:
Article
Self‐Assembly Behavior and Application of Terphenyl‐Cored Trimaltosides for Membrane‐Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability.
Published in:
Chemistry - A European Journal, 2019, v. 25, n. 49, p. 11545, doi. 10.1002/chem.201902468
By:
- Ehsan, Muhammad;
- Du, Yang;
- Mortensen, Jonas S.;
- Hariharan, Parameswaran;
- Qu, Qianhui;
- Ghani, Lubna;
- Das, Manabendra;
- Grethen, Anne;
- Byrne, Bernadette;
- Skiniotis, Georgios;
- Keller, Sandro;
- Loland, Claus J.;
- Guan, Lan;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
An Engineered Lithocholate‐Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.
Published in:
Chemistry - A European Journal, 2018, v. 24, n. 39, p. 9860, doi. 10.1002/chem.201801141
By:
- Das, Manabendra;
- Du, Yang;
- Mortensen, Jonas S.;
- Bae, Hyoung Eun;
- Byrne, Bernadette;
- Loland, Claus J.;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.
Published in:
Chemistry - A European Journal, 2017, v. 23, n. 28, p. 6724, doi. 10.1002/chem.201605016
By:
- Hussain, Hazrat;
- Du, Yang;
- Tikhonova, Elena;
- Mortensen, Jonas S.;
- Ribeiro, Orquidea;
- Santillan, Claudia;
- Das, Manabendra;
- Ehsan, Muhammad;
- Loland, Claus J.;
- Guan, Lan;
- Kobilka, Brian K.;
- Byrne, Bernadette;
- Chae, Pil Seok
Publication type:
Article
Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.
Published in:
Chemistry - A European Journal, 2016, v. 22, n. 52, p. 18833, doi. 10.1002/chem.201603338
By:
- Cho, Kyung Ho;
- Ribeiro, Orquidea;
- Du, Yang;
- Tikhonova, Elena;
- Mortensen, Jonas S.;
- Markham, Kelsey;
- Hariharan, Parameswaran;
- Loland, Claus J.;
- Guan, Lan;
- Kobilka, Brian K.;
- Byrne, Bernadette;
- Chae, Pil Seok
Publication type:
Article
Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.
Published in:
Chemistry - A European Journal, 2016, v. 22, n. 21, p. 7068, doi. 10.1002/chem.201600533
By:
- Hussain, Hazrat;
- Du, Yang;
- Scull, Nicola J.;
- Mortensen, Jonas S.;
- Tarrasch, Jeffrey;
- Bae, Hyoung Eun;
- Loland, Claus J.;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
Transition metal ion FRET uncovers K<sup>+</sup> regulation of a neurotransmitter/sodium symporter.
Published in:
Nature Communications, 2016, v. 7, n. 9, p. 12755, doi. 10.1038/ncomms12755
By:
- Billesbølle, Christian B.;
- Mortensen, Jonas S.;
- Sohail, Azmat;
- Schmidt, Solveig G.;
- Shi, Lei;
- Sitte, Harald H.;
- Gether, Ulrik;
- Loland, Claus J.
Publication type:
Article
Elucidating the Mechanism Behind Sodium-Coupled Neurotransmitter Transporters by Reconstitution.
Published in:
Neurochemical Research, 2022, v. 47, n. 1, p. 127, doi. 10.1007/s11064-021-03413-y
By:
- Schmidt, Solveig G.;
- Gether, Ulrik;
- Loland, Claus J.
Publication type:
Article
The Environment Shapes the Inner Vestibule of LeuT.
Published in:
PLoS Computational Biology, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.pcbi.1005197
By:
- Sohail, Azmat;
- Jayaraman, Kumaresan;
- Venkatesan, Santhoshkannan;
- Gotfryd, Kamil;
- Daerr, Markus;
- Gether, Ulrik;
- Loland, Claus J.;
- Wanner, Klaus T.;
- Freissmuth, Michael;
- Sitte, Harald H.;
- Sandtner, Walter;
- Stockner, Thomas
Publication type:
Article
The binding sites for cocaine and dopamine in the dopamine transporter overlap.
Published in:
Nature Neuroscience, 2008, v. 11, n. 7, p. 780, doi. 10.1038/nn.2146
By:
- Beuming, Thijs;
- Kniazeff, Julie;
- Bergmann, Marianne L.;
- Lei Shi;
- Gracia, Luis;
- Raniszewska, Klaudia;
- Newman, Amy Hauck;
- Javitch, Jonathan A.;
- Weinstein, Harel;
- Gether, Ulrik;
- Loland, Claus J.
Publication type:
Article
Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.
Published in:
2016
By:
- Larsen, M Andreas B;
- Plenge, Per;
- Andersen, Jacob;
- Eildal, Jonas NN;
- Kristensen, Anders S;
- Bøgesø, Klaus P;
- Gether, Ulrik;
- Strømgaard, Kristian;
- Bang ‐ Andersen, Benny;
- Loland, Claus J;
- Eildal, Jonas N N;
- Bøgesø, Klaus P;
- Strømgaard, Kristian;
- Bang-Andersen, Benny
Publication type:
journal article
3,4‐Bis(hydroxymethyl)hexane‐1,6‐diol‐based Maltosides (HDMs) for Membrane‐Protein Study: Importance of Detergent Rigidity–Flexibility Balance in Protein Stability.
Published in:
Chemistry - An Asian Journal, 2022, v. 17, n. 24, p. 1, doi. 10.1002/asia.202200941
By:
- Lee, Hyun Sung;
- Das, Manabendra;
- Mahler, Florian;
- Ahmed, Waqar;
- Wang, Haoqing;
- Mortensen, Jonas S.;
- Hariharan, Parameswaran;
- Ghani, Lubna;
- Byrne, Bernadette;
- Guan, Lan;
- Loland, Claus J.;
- Keller, Sandro;
- Chae, Pil Seok
Publication type:
Article
Self‐Assembly Behaviors of a Penta‐Phenylene Maltoside and Its Application for Membrane Protein Study.
Published in:
Chemistry - An Asian Journal, 2019, v. 14, n. 11, p. 1926, doi. 10.1002/asia.201900224
By:
- Ehsan, Muhammad;
- Kumar, Ashwani;
- Mortensen, Jonas S.;
- Du, Yang;
- Hariharan, Parameswaran;
- Kumar, Kaavya K.;
- Ha, Betty;
- Byrne, Bernadette;
- Guan, Lan;
- Kobilka, Brian K.;
- Loland, Claus J.;
- Chae, Pil Seok
Publication type:
Article
Foldable Detergents for Membrane Protein Study: Importance of Detergent Core Flexibility in Protein Stabilization.
Published in:
Chemistry - A European Journal, 2022, v. 28, n. 21, p. 1, doi. 10.1002/chem.202200116
By:
- Ghani, Lubna;
- Kim, Seonghoon;
- Wang, Haoqing;
- Lee, Hyun Sung;
- Mortensen, Jonas S.;
- Katsube, Satoshi;
- Du, Yang;
- Sadaf, Aiman;
- Ahmed, Waqar;
- Byrne, Bernadette;
- Guan, Lan;
- Loland, Claus J.;
- Kobilka, Brian K.;
- Im, Wonpil;
- Chae, Pil Seok
Publication type:
Article
Fluorescent non-canonical amino acid provides insight into the human serotonin transporter.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53584-9
By:
- Nygaard, Andreas;
- Zachariassen, Linda G.;
- Larsen, Kathrine S.;
- Kristensen, Anders S.;
- Loland, Claus J.
Publication type:
Article
Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.
Published in:
Chemistry - A European Journal, 2015, v. 21, n. 28, p. 10008, doi. 10.1002/chem.201501083
By:
- Cho, Kyung Ho;
- Du, Yang;
- Scull, Nicola J.;
- Hariharan, Parameswaran;
- Gotfryd, Kamil;
- Loland, Claus J.;
- Guan, Lan;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Chae, Pil Seok
Publication type:
Article
Novel Tripod Amphiphiles for Membrane Protein Analysis.
Published in:
Chemistry - A European Journal, 2013, v. 19, n. 46, p. 15645, doi. 10.1002/chem.201301423
By:
- Chae, Pil Seok;
- Kruse, Andrew C.;
- Gotfryd, Kamil;
- Rana, Rohini R.;
- Cho, Kyung Ho;
- Rasmussen, Søren G. F.;
- Bae, Hyoung Eun;
- Chandra, Richa;
- Gether, Ulrik;
- Guan, Lan;
- Kobilka, Brian K.;
- Loland, Claus J.;
- Byrne, Bernadette;
- Gellman, Samuel H.
Publication type:
Article
Corrigendum: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins.
Published in:
Chemistry - A European Journal, 2013, v. 19, n. 16, p. 4964, doi. 10.1002/chem.201300856
By:
- Chae, Pil Seok;
- Rasmussen, Søren G. F.;
- Rana, Rohini R.;
- Gotfryd, Kamil;
- Kruse, Andrew C.;
- Manglik, Aashish;
- Cho, Kyung Ho;
- Nurva, Shailika;
- Gether, Ulrik;
- Guan, Lan;
- Loland, Claus J.;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Gellman, Samuel H.
Publication type:
Article
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins.
Published in:
Chemistry - A European Journal, 2012, v. 18, n. 31, p. 9485, doi. 10.1002/chem.201200069
By:
- Chae, Pil Seok;
- Rasmussen, Søren G. F.;
- Rana, Rohini R.;
- Gotfryd, Kamil;
- Kruse, Andrew C.;
- Manglik, Aashish;
- Cho, Kyung Ho;
- Nurva, Shailika;
- Gether, Ulrik;
- Guan, Lan;
- Loland, Claus J.;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Gellman, Samuel H.
Publication type:
Article
Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012).
Published in:
Chemistry - A European Journal, 2012, v. 18, n. 31, p. 9434, doi. 10.1002/chem.201290131
By:
- Chae, Pil Seok;
- Rasmussen, Søren G. F.;
- Rana, Rohini R.;
- Gotfryd, Kamil;
- Kruse, Andrew C.;
- Manglik, Aashish;
- Cho, Kyung Ho;
- Nurva, Shailika;
- Gether, Ulrik;
- Guan, Lan;
- Loland, Claus J.;
- Byrne, Bernadette;
- Kobilka, Brian K.;
- Gellman, Samuel H.
Publication type:
Article
Transmembrane transporter proteins: Capturing transport in motion.
Published in:
Basic & Clinical Pharmacology & Toxicology, 2024, v. 134, n. 2, p. 203, doi. 10.1111/bcpt.13960
By:
- Loland, Claus J.;
- Wellendorph, Petrine;
- Pedersen, Stine F.;
- Gether, Ulrik
Publication type:
Article
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15292-y
By:
- Plenge, Per;
- Abramyan, Ara M.;
- Sørensen, Gunnar;
- Mørk, Arne;
- Weikop, Pia;
- Gether, Ulrik;
- Bang-Andersen, Benny;
- Shi, Lei;
- Loland, Claus J.
Publication type:
Article
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14735-w
By:
- Gotfryd, Kamil;
- Boesen, Thomas;
- Mortensen, Jonas S.;
- Khelashvili, George;
- Quick, Matthias;
- Terry, Daniel S.;
- Missel, Julie W.;
- LeVine, Michael V.;
- Gourdon, Pontus;
- Blanchard, Scott C.;
- Javitch, Jonathan A.;
- Weinstein, Harel;
- Loland, Claus J.;
- Nissen, Poul;
- Gether, Ulrik
Publication type:
Article

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