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- Title
Hormonal and temperature responses to the 5-HT[sub 1A] receptor agonist flesinoxan in normal volunteers.
- Authors
Pitchot, William; Wauthy, Jacques; Hansenne, Michel; Pinto, Emmanuel; Fuchs, Sonia; Reggers, Jean; Legros, Jean-Jacques; Ansseau, Marc
- Abstract
Rationale: Flesinoxan is a highly potent and selective 5-HT[sub 1A] agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. Objectives: We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. Methods: In a doubleblind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min. Results: Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. Conclusions: These results showed the role of 5-HT[sub 1A] mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.
- Subjects
NEUROTRANSMITTER receptors; SEROTONIN
- Publication
Psychopharmacology, 2002, Vol 164, Issue 1, p27
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-002-1177-0