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- Title
Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT[sub 2] receptors.
- Authors
Sargent, P. A.; Quested, D. J.; Cowen, P. J.
- Abstract
Abstract We measured the cortisol response to the 5-HT precursor, 5-hydroxytryptophan, (5-HTP) in seven patients with major depression before and after 8 weeks treatment with the tricyclic antidepressant, clomipramine. The cortisol response to 5-HTP was significantly increased following clomipramine treatment, suggesting that clomipramine, like selective serotonin re-uptake inhibitors (SSRIs), enhances this 5-HT[sub 2] receptor mediated response. Because other tricyclic antidepressants do not increase 5-HTP-mediated cortisol release, it seems unlikely that enhancement of 5-HT[sub 2] receptor function is a critical mechanism for antidepressant action. However, facilitation of neurotransmission at 5-HT[sub 2] receptors could account for the efficacy of clomipramine and SSRIs in the treatment of obsessive compulsive disorder and also for their liability to cause orgasmic dysfunction.
- Subjects
HYDROXYTRYPTOPHAN; ANTIDEPRESSANTS; SEROTONIN uptake inhibitors; HYDROCORTISONE
- Publication
Psychopharmacology, 1998, Vol 140, Issue 1, p120
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s002130050747