We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Advancements in anti-tuberculosis drug potentiators: targeting mechanisms of tuberculosis resistance.
- Authors
Jianhui Yang; Xiao Wang; Jinbo Zhang; Yishuang Liu
- Abstract
Tuberculosis (TB) constitutes a formidable global health challenge, exacerbated by the rise of multidrug-resistant TB (MDR-TB) strains. The effectiveness of anti-TB drugs has been hindered by this emergence of resistance. To address this, the development of synergistic compounds, informed by drug resistance mechanisms, holds promise for mitigating resistance emergence and shortening treatment durations. This review focuses on the amalgamation of anti-TB drugs with potentiators targeting the cell wall, efflux pump, and β-lactamase. Our aim is to offer insights that guide the future development of novel potentiators with enhanced efficacy and reduced toxicity.
- Subjects
ANTITUBERCULAR agents; TUBERCULOSIS; MULTIDRUG-resistant tuberculosis; DRUG efficacy; DRUG resistance; TREATMENT duration; WORLD health
- Publication
Journal of Chinese Pharmaceutical Sciences, 2024, Vol 33, Issue 2, p89
- ISSN
1003-1057
- Publication type
Article
- DOI
10.5246/jcps.2024.02.008