We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Continuous Subcutaneous Recombinant Parathyroid Hormone (1–34) Infusion in the Management of Childhood Hypoparathyroidism Associated with Malabsorption.
- Authors
Saraff, Vrinda; Rothenbuhler, Anya; Högler, Wolfgang; Linglart, Agnès
- Abstract
<bold><italic>Background/Aims:</italic></bold> Hypoparathyroidism associated with malabsorption can be particularly challenging to manage due to limited and erratic intestinal absorption of calcium and vitamin D analogues, resulting in episodes of hypo- or hypercalcaemia. We evaluated the role of continuous subcutaneous recombinant parathyroid hormone (rhPTH 1–34) infusion (CSPI) in children with hypoparathyroidism associated with intestinal malabsorption resistant to conventional therapy. <bold><italic>Method:</italic></bold> Four patients (8–13 years of age), with symptomatic hypocalcaemia resistant to conventional therapy, were started on CSPI (follow-up 3–8 years) in two paediatric endocrinology units in Europe. <bold><italic>Results:</italic></bold> Serum calcium normalized within 48 h of commencing treatment in all 4 patients. An average rhPTH 1–34 dose of 0.4 µg/kg/day resulted in a substantial reduction in symptomatic hypocalcaemia and hypo-/hypercalcaemia-related hospital admissions. An increased alkaline phosphatase activity was noted in the first 6 months on CSPI, indicating an increase in bone turnover. In 2 patients with elevated urinary calcium excretion before CSPI, this normalized in the first year on treatment. No significant side effects were noticed in the short or long term, with patient-reported preference of CSPI over conventional treatment. <bold><italic>Conclusion:</italic></bold> CSPI is a promising and effective treatment option for managing hypocalcaemia and hyperphosphataemia in children with hypoparathyroidism associated with intestinal malabsorption.
- Subjects
PARATHYROID hormone; HYPOPARATHYROIDISM; MALABSORPTION syndromes; THERAPEUTICS
- Publication
Hormone Research in Paediatrics, 2018, Vol 89, Issue 4, p271
- ISSN
1663-2818
- Publication type
Article
- DOI
10.1159/000479867