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- Title
Preoperative Prognostic Nutrition Index as a Prognostic Indicator of Survival in Elderly Patients Undergoing Gastric Cancer Surgery.
- Authors
Zhang, Xiaonan; Fang, Huimin; Zeng, Zhigang; Zhang, Kaijun; Lin, Zhanyi; Deng, Gang; Deng, Weiping; Guan, Lichang; Wei, Xuebiao; Li, Xinyi; Jiang, Lei; Xu, Lishu
- Abstract
Purpose: Gastric cancer is a common tumor type associated with nutritional and immune status. The aim of the current study was to investigate the prognostic value of a preoperative prognostic nutritional index (PNI), composed of nutritional factors and immune factors in elderly patients undergoing gastric cancer surgery. Patients and Methods: A total of 454 patients undergoing gastric cancer surgery were divided into two groups based on preoperative PNI scores: ≤ 45.1 (n = 307) and > 45.1 (n = 147). Survival analysis was performed using the Kaplan–Meier method and Log rank tests. Univariate and multivariate analyses were conducted to identify independent prognostic factors using a Cox proportional hazards model. Results: According to the X-tile program, the optimal cutoff value for predicting overall survival (OS) with the PNI was 45.1. The receiver operating characteristic analysis revealed that PNI exhibited 70.6% sensitivity and 56.5% specicity for predicting death during long-term follow-up. The cumulative incidence of postoperative 4-year mortality indicated that the risk of death increased significantly for PNI ≤ 45.1. In multivariate analysis, preoperative PNI was a significant independent predictor of mortality. In the age-stratified subgroup analysis, preoperative PNI was more sensitive for the old elderly subgroup than for the young elderly subgroup. Conclusion: Preoperative PNI is a sensitive and specific prognostic predictor among elderly patients undergoing gastric cancer surgery.
- Subjects
OVERALL survival; OLDER patients; STOMACH cancer; ONCOLOGIC surgery; PROGNOSIS; PROPORTIONAL hazards models
- Publication
Cancer Management & Research, 2021, Vol 13, p5263
- ISSN
1179-1322
- Publication type
Article
- DOI
10.2147/CMAR.S316437