We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Angiotensin-Converting Enzyme Gene Polymorphism Is Associated with Vulnerability to Alcoholic Cardiomyopathy.
- Authors
FernáNdez-Solà, Joaquim; Nicolás, Josep María; Oriola, Josep; Sacanella, Emilio; Estruch, Ramón; Rubin, Emanuel; Urbano-Márquez, Alvaro
- Abstract
Background: Chronic alcohol abuse has a dose-dependent toxic effect on the myocardium, leading to alcoholic cardiomyopathy. The fact that only a minority of persons with chronic alcoholism have this condition suggests the possibility of a genetic vulnerability. In this context, polymorphism of the angiotensin-converting enzyme (ACE) gene has been implicated in cardiac dysfunction. Objective: To compare the ACE genotypes of alcoholic persons who have cardiomyopathy with those of comparable alcohol abusers who have normal cardiac function. Design: Case-control study over a 2-year period. Setting: An academic tertiary referral hospital in Barcelona, Spain. Patients: 30 alcoholic men with symptomatic cardiomyopathy and 27 alcoholic men with normal cardiac function. Measurements: Ethanol intake, cardiac status, left ventricular ejection fraction (LVEF), and ACE gene polymorphism. Results: The DD ACE genotype was present in 57% of alcoholic persons with an LVEF less than 0.50 and in 7% of those with normal cardiac function. Compared with persons who had an I allele, the odds ratio for development of left ventricular dysfunction in alcoholic persons with the DD genotype was 16.4. Conclusions: Vulnerability to cardiomyopathy among chronic alcohol abusers is partially genetic and is related to presence of the ACE DD genotype. This finding demonstrates genetic susceptibility to alcohol-induced myocardial damage.
- Subjects
CARDIOMYOPATHIES; ALCOHOL drinking; ANGIOTENSIN converting enzyme; ALCOHOLIC cardiomyopathy; CARDIOVASCULAR diseases risk factors
- Publication
Annals of Internal Medicine, 2002, Vol 137, Issue 5, p321
- ISSN
0003-4819
- Publication type
Article
- DOI
10.7326/0003-4819-137-5_Part_1-200209030-00007