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- Title
BIOASSAY-GUIDED ISOLATION AND IDENTIFICATION OF AN ANTIBACTERIAL COMPOUND FROM FERULA PERSICA VAR. PERSICA ROOTS.
- Authors
Shahverdi, Ahmad-Reza; Iranshahi, Mehrdad; Mirjani, Roohollah; Jamalifar, Hossein; Amin, Gholamreza; Shafiee, Abbas
- Abstract
The antibacterial activities of the chloroform and water extracts of Ferula persica var. persica (Apiaceae) roots were studied by the disk diffusion method. While the chloroform extract of F. persica roots showed antibacterial activity, the water extract of the roots at the concentrations that tested did not show any activity. By bioassay-guided fractionation of the chloroform extract of the roots by preparative thin layer chromatography (PTLC) a compound was found which was active against some bacteria. By conventional spectroscopy methods the active fraction was identified as umbelliprenin. This coumarin was mostly active against B. subtillis, B. cereus, E. coli, K. ponumoniae, S. typhi, S. aureus, and S. epidermilis.
- Subjects
CHLOROFORM; ANESTHETICS; FERULA; CHROMATOGRAPHIC analysis; UMBELLIFERAE
- Publication
DARU: Journal of Pharmaceutical Sciences, 2005, Vol 13, Issue 1, p17
- ISSN
1560-8115
- Publication type
Article