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- Title
Latent thyroid dysfunction in elderly patients with persistent nonvalvular atrial fibrillation.
- Authors
Gheorghe, Gabriela Silvia; Hodorogea, Andreea Simona; Parvu, Irina; Iliesiu, Adriana Mihaela; Ciobanu, Ana; Nanea, Ioan Tiberiu
- Abstract
Purpose -- The objective of this study was to evaluate the prevalence of subclinical thyroid dysfunction in patients(pts) aged over 60 admitted to a cardiology department for persistent atrial fibrillation (AF). Methods -- Inclusion criteria were: age over 60, persistent nonvalvular AF, hospitalized within 6 months, beta blocker therapy at maximum dose. Exclusion criteria were: acute coronary syndromes, known thyroid disease, treatment with amiodarone, thyroid changes on ultrasound, congestive heart failure class III/IV, left ventricular ejection fraction (LVEF)<40%, severe comorbidities. In all patients cardiovascular history was noted, TSH, freeT4 (FT4) were determined and thyroid ultrasound was performed. Patients with TSH and FT4 within normal ranges were considered euthyroid, those with TSH below 0.1 mU/L and normal FT4 were diagnosed with clinically latent hyperthyroidism and those with TSH over 6.5 mU/L and normal FT4 with clinically latent hypothyroidism. Results -- 290 patients were included, 52.2% men, mean age 72.14±12, mean LVEF 48.4±4%. 274 patients were euthyroid, 6(2%) had subclinical hypothyroidism and 10(3.44%) subclinical hyperthyroidism, with mean resting heart rate (HR)10 beats/min more than euthyroid pts. Conclusions -- Clinically latent hyperthyroidism was found in 3.4% of patients with persistent AF aged over 60, with higher prevalence than in the general population and higher rest HR than in euthyroid patients. Latent hypothyroidism was found in 2% of patients with persistent AF, to a lesser extent than in the general population.
- Subjects
THYROID diseases; ATRIAL fibrillation; HYPERTHYROIDISM
- Publication
Romanian Journal of Cardiology, 2016, Vol 26, Issue 4, p455
- ISSN
1220-658X
- Publication type
Article