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- Title
Zn (II), Cu (II), Co (II), and Ni (II) complexes bearing aza-heterocyclic ligands: synthesis, characterization, and anticancer activities.
- Authors
Nazeer, Amir; Umar, Qasim; Yang, Yanting; Luo, Mei
- Abstract
Due to their structural arrangements, coordination complexes have shown potential to combat various human diseases. Nitrogen heteroatoms are a fascinating class of coordination compounds with many applications in synthesis and medicine. Herein, four Co(II), Zn(II), Cu(II), and Ni(II) complexes (I–IV) such as [CoC10H14Cl2N6O2] (I), [ZnC6H10Cl2N6O2] (II), [Cu2C16H34N2O12] (III), and [Ni4C80H100N16O22] (IV) bearing aza-heterocyclic ligands have been synthesized under one-pot self-assembly conditions. The reaction of 2-amino-4-hydroxy-6-methylpyrimidine and 3-amino-5-hydroxypyrazole with CoCl2·6H2O and ZnCl2, respectively, produced two mononuclear complexes (I)–(II) while two binuclear complexes (III)–(IV) (complex IV are in two halves) were synthesized using Cu (OAC)2·H2O and NiCl2·6H2O, respectively, with salicylidene salicylhydrazide. Then, the complexes were characterized using NMR, FTIR UV–Vis, X-ray diffraction, TGA, and elemental analysis techniques to confirm their structures. The synthesis complexes were employed against different human tumour cell lines (SMMC-7721, A549, MDA-MB-231, and SW480). The best activity was demonstrated by complex (II) against human tumour cell lines SMMC-7721 (liver cancer cell) with an IC50 value of (6.356 µM).
- Subjects
COPPER; TRANSITION metal complexes; ANTINEOPLASTIC agents; COORDINATION compounds; LIVER cells; LIVER cancer
- Publication
Journal of the Iranian Chemical Society, 2024, Vol 21, Issue 6, p1599
- ISSN
1735-207X
- Publication type
Article
- DOI
10.1007/s13738-024-03021-x