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- Title
Repurposing Drugs in Oncology (ReDO)--mebendazole as an anti-cancer agent.
- Authors
Pantziarka, Pan; Bouche, Gauthier; Meheus, Lydie; Sukhatme, Vidula; Sukhatme, Vikas P.
- Abstract
Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer therapeutic is warranted. A number of possible combinations with other drugs are discussed in the Appendix.
- Subjects
MEBENDAZOLE; DRUG development; CANCER chemotherapy
- Publication
Ecancermedicalscience, 2014, Vol 8, Issue 413-446, p1
- ISSN
1754-6605
- Publication type
Case Study
- DOI
10.3332/ecancer.2014.443