We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats.
- Authors
Gong, Yan; Chang, Zhan-Ping; Ren, Ruo-Tong; Wei, Shi-hui; Zhou, Huan-Fen; Chen, Xiao-fei; Hou, Bao-ke; Jin, Xin; Zhang, Mao-nian
- Abstract
Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy.
- Subjects
DIABETIC retinopathy; GENE therapy; ADENO-associated virus; BRAIN-derived neurotrophic factor; RETINAL ganglion cells; RATS
- Publication
Cellular & Molecular Neurobiology, 2012, Vol 32, Issue 3, p467
- ISSN
0272-4340
- Publication type
Article
- DOI
10.1007/s10571-011-9779-x