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- Title
Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression.
- Authors
Siew Hong Lam; Yi Lian Wu; Vega, Vinsensius B; Miller, Lance D; Spitsbergen, Jan; Yan Tong; Huiqing Zhan; Govindarajan, Kunde R; Serene Lee; Mathavan, Sinnakarupan; Krishna Murthy, Karuturi R; Buhler, Donald R; Edison T Liu; Zhiyuan Gong
- Abstract
The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.
- Subjects
ZEBRA danio; CANCER research; GENE expression; CANCER invasiveness; GENETIC regulation
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 1, p73
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1169