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- Title
Monoclonal gammopathy of undetermined significance: a consensus statement.
- Authors
Berenson, James R.; Anderson, Kenneth C.; Audell, Robert A.; Boccia, Ralph V.; Coleman, Morton; Dimopoulos, Meletios A.; Drake, Matthew T.; Fonseca, Rafael; Harousseau, Jean-Luc; Joshua, Douglas; Lonial, Sagar; Niesvizky, Ruben; Palumbo, Antonio; Roodman, G. David; San-Miguel, Jesus F.; Singhal, Seema; Weber, Donna M.; Zangari, Maurizio; Wirtschafter, Eric; Yellin, Ori
- Abstract
On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non-malignant B-cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B-cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow-up patients with MGUS. The panel also addressed the identification and treatment of MGUS-related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.
- Subjects
PLASMA cell diseases; BONE diseases; B cells; MONOCLONAL gammopathies; NEUROPATHY
- Publication
British Journal of Haematology, 2010, Vol 150, Issue 1, p28
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2010.08207.x