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- Title
International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia.
- Authors
Lehrnbecher, Thomas; Ethier, Marie-Chantal; Zaoutis, Theoklis; Creutzig, Ursula; Gamis, Alan; Reinhardt, Dirk; Aplenc, Richard; Sung, Lillian
- Abstract
This study described infection-related supportive care practices amongst centres participating in two large paediatric acute myeloid leukaemia (AML) cooperative groups, Children’s Oncology Group (COG) and Berlin-Frankfurt-Muenster (BFM). We surveyed 216 COG and 55 BFM institutions. The overall survey response rate was 83·8%. Antibacterial prophylaxis was more common among BFM (15/46, 32·6%) compared to COG (24/180, 13·3%, P < 0·0001) institutions. Antifungal prophylaxis also was more common among BFM (42/46, 91·3%) compared to COG (137/178, 77·0%, P = 0·03). There were systematic differences in infection-related supportive care practices. This information may be used to encourage harmonization of supportive care practices and future randomized trials.
- Subjects
GERMANY; ACUTE myeloid leukemia in children; PEDIATRICS; HEMATOLOGY; MEDICAL care; ANTIFUNGAL agents
- Publication
British Journal of Haematology, 2009, Vol 147, Issue 1, p125
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2009.07844.x