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- Title
Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma.
- Authors
Pratt, G.; Fenton, J. A. L.; Davies, F. E.; Rawstron, A. C.; Richards, S. J.; Collins, J. E.; Owen, R. G.; Jack, A. S.; Smith, G. M.; Morgan, G. J.
- Abstract
The majority of patients with multiple myeloma have translocations involving the immunoglobulin heavy chain switch regions on chromosome 14q32 and a promiscuous range of partner chromosomes. We describe a patient with an insertion of 132 bp of chromosome 22q12 sequence into the 5′ region flanking Sμ on chromosome 14q32. The 132 bp region from chromosome 22q12 contains the whole of exon 3 from a novel gene of unknown function in man. The significance of such insertional events remains unclear. The description of insertional events occurring as a result of abnormal switch recombination suggests that, in myeloma, dysregulation of oncogenes may occur by a mechanism other than chromosomal translocation.
- Subjects
IMMUNOGLOBULINS; MULTIPLE myeloma
- Publication
British Journal of Haematology, 2001, Vol 112, Issue 2, p388
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2001.02588.x