We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anti-interleukin-8 auto-antibodies in cerebrospinal fluid of children with purulent meningitis.
- Authors
Takasaki, Jiro; Ogawa, Yunosuke; Takasaki,, Jiro
- Abstract
AbstractBackground: Cerebrospinal fluid (CSF) of patients with purulent meningitis contains a high concentration of interleukin (IL)-8. Recently, the presence of anti-IL-8 auto-antibodies was noted in blood and alveolar fluid. Therefore, measurement of the concentration of anti-IL-8 auto-antibodies was attempted in CSF of children with and without meningitis. Methods and Results: We measured the concentration of anti-IL-8 auto-antibodies in CSF of children with purulent or aseptic meningitis and those without meningitis. The CSF obtained on admission showed a significantly higher concentration of anti-IL-8 IgG and IgM auto-antibodies in children with purulent meningitis, compared with those with aseptic meningitis or without meningitis. Among the three groups of children, the concentration of IL-8 was also significantly higher in CSF of children with purulent meningitis. Conclusion: Because the anti-IL-8 IgG auto-antibody binds to IL-8 and inhibits IL-8 interaction with specific receptors on neutrophils, the presence of anti-IL-8 auto-antibodies seems to provide a mechanism that limits the bioavailability of free IL-8 in CSF.
- Subjects
INTERLEUKIN-8; CEREBROSPINAL fluid; CEREBROSPINAL meningitis; JUVENILE diseases
- Publication
Pediatrics International, 2000, Vol 42, Issue 2, p139
- ISSN
1328-8067
- Publication type
Article
- DOI
10.1046/j.1442-200X.2000.01198.x