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- Title
Ceftaroline-Induced Eosinophilic Pneumonia.
- Authors
Desai, Kunal R.; Burdette, Steven D.; Polenakovik, Hari M.; Hagaman, Jared; Pleiman, Craig M.
- Abstract
We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug-induced eosinophilic pneumonia.
- Subjects
ADVERSE health care events; METHICILLIN-resistant staphylococcus aureus treatment; DYSPNEA; HYPOXEMIA; BRONCHOALVEOLAR lavage; LUNG disease diagnosis
- Publication
Pharmacotherapy, 2013, Vol 33, Issue 7, pe166
- ISSN
0277-0008
- Publication type
Article
- DOI
10.1002/phar.1286