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- Title
PyBidine/Copper Catalyst: Asymmetric exo'-Selective [3+2] Cycloaddition using Imino Ester and Electrophilic Indole.
- Authors
Awata, Atsuko; Arai, Takayoshi
- Abstract
Electrophilic indoles having two electron-withdrawing groups undergo nucleophilic attack at C2 and electrophilic functionalization at C3. This is the first enantioselective formal [3+2] cycloaddition using electrophilic indoles. The PyBidine/ Cu catalyst smoothly promoted highly enantio- and exo'- selective [3+2] cycloaddition using imino esters and 3-nitroindoles. This reaction provides a method for the preparation of diverse and complex chiral pyrroloindoline compounds.
- Subjects
IMIDAZOLIDINES; COPPER catalysts; INDOLE derivatives; PYRIDINE derivatives; ENANTIOSELECTIVE catalysis; RING formation (Chemistry); ELECTROPHILES; ASYMMETRIC synthesis
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 39, p10630
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201405223