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- Title
Analysis of different contrast enhancement patterns after microbubble-based contrast agent injection in liver hemangiomas with atypical appearance on baseline scan.
- Authors
Quaia, E.; Bartolotta, T. V.; Midiri, M.; Cernic, S.; Belgrano, M.; Cova, M.
- Abstract
<bold>Background: </bold>We describe different possible enhancement patterns in liver hemangiomas with atypical appearance on baseline ultrasound after microbubble-based contrast agent injection. <bold>Methods: </bold>From a series of 253 consecutive lesions that were indeterminate on baseline ultrasound and then scanned after injection of air-filled microbubble contrast agent, 65 focal liver lesions were retrospectively selected on the basis of a diagnosis of liver hemangioma on multiphase contrast-enhanced computed tomography (n = 23), magnetic resonance imaging (n = 27), or histology (n = 15). Each lesion was scanned during arterial phase (30 s after microbubble injection) and late phase (5 min after injection). On-site sonologists performed retrospective assessment of contrast-enhancement patterns by consensus. <bold>Results: </bold>Centripetal fill-in preceded (n = 50) or not preceded (n = 3) by peripheral nodular/rim-like enhancement was the prevalently observed contrast-enhancement pattern, equivalent to the typical enhancement pattern of liver hemangiomas on contrast-enhanced computed tomography or magnetic resonance imaging. In the remaining lesions, additional enhancement patterns (diffuse contrast enhancement with rapid fill-in and a late hyper-isoechoic appearance, n = 6; peripheral nodular enhancement with a late hypoechoic appearance, n = 3; or persistent heterogeneous and hyperechoic appearance, n = 3) were observed. <bold>Conclusion: </bold>Different contrast-enhancement patterns are possible in atypical liver hemangiomas after microbubble injection. Typical centripetal fill-in is the prevalent pattern and its evidence allows diagnosis.
- Subjects
HEMANGIOMAS; ANGIOMAS; TOMOGRAPHY; BLOOD-vessel tumors; MAGNETIC resonance imaging; GASTROENTEROLOGY
- Publication
Abdominal Imaging, 2006, Vol 31, Issue 1, p59
- ISSN
0942-8925
- Publication type
journal article
- DOI
10.1007/s00261-005-0358-9