We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis.
- Authors
Samec, Marek; Liskova, Alena; Koklesova, Lenka; Samuel, Samson Mathews; Murin, Radovan; Zubor, Pavol; Bujnak, Jan; Kwon, Taeg Kyu; Büsselberg, Dietrich; Prosecky, Robert; Caprnda, Martin; Rodrigo, Luis; Ciccocioppo, Rachele; Kruzliak, Peter; Kubatka, Peter
- Abstract
The role of immune system in carcinogenesis represents fundamental events associated with cancer eradication; however, tumor evolution is connected with various mechanisms of tumor evasion and progression of cancer. Based on recent evidence, phytochemicals are directly associated with immunomodulation of the innate and adaptive immunity via different mechanisms of action including stimulation and amplification of immune cells, humoral compartments, and associated molecules. This comprehensive study focuses on immunomodulating potential of phytochemicals (mixture in plants or separately such as individual phytochemical) and their impact on regulation of immune response during cancer development, immune tolerance, and immune escape. Clinical application of phytochemicals as modulators of host immunity against cancer may represent perspective approach in anticancer therapy.
- Subjects
IMMUNOREGULATION; HUMAN carcinogenesis; IMMUNOLOGICAL tolerance; HUMORAL immunity; IMMUNE system; CANCER invasiveness; NATURAL immunity
- Publication
Journal of Cancer Research & Clinical Oncology, 2020, Vol 146, Issue 12, p3137
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-020-03424-2